neural differentiation

By Targets:	Akt (1) AMPK (1) Apoptosis (1) Bacterial (3) Calcium Channel (2) Casein Kinase (2) CDK (2) Endogenous Metabolite (3) Estrogen Receptor/ERR (3) GPR55 (1) HDAC (1) NF-κB (1) Phosphodiesterase (PDE) (1) Ribosomal S6 Kinase (RSK) (2) SGK (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Endocrinology (2) Inflammation/Immunology (2) Neurological Disease (11)

Targets Recommended: CD3 CD6 CD2 Neprilysin FLT3 Anaplastic lymphoma kinase (ALK) P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10591

Neuropathiazol	Others	Neurological Disease
Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells .

HY-117348

NCC-149

HDAC Neurological Disease

NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research .

NCC-149	HDAC	Neurological Disease
NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research .

HY-B0141

Estradiol Maximum Cited Publications 56 Publications Verification β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Endocrinology Cancer
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-B0141C

Estradiol hemihydrate β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Neurological Disease Cancer
Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-N2740

Agalloside

Others Neurological Disease

Agalloside is a neural stem cell differentiation activator that can be found in Aquilaria agallocha .
HY-12323G

ISX-9

Isoxazole 9
Calcium Channel Cardiovascular Disease Neurological Disease

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation.

Agalloside	Others	Neurological Disease
Agalloside is a neural stem cell differentiation activator that can be found in Aquilaria agallocha .

ISX-9 Isoxazole 9	Calcium Channel	Cardiovascular Disease Neurological Disease
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation.

HY-N1838

Dehydromaackiain	Others	Neurological Disease
Dehydromaackiain is a potent Neurogenin2 (Ngn2) promoter activator. Dehydromaackiain promotes differentiation of neural stem cells into neurons .

HY-B0141R

Estradiol (Standard) Maximum Cited Publications 56 Publications Verification β-Estradiol(Standard); E2(Standard); 17β-Estradiol(Standard); 17β-Oestradiol (Standard)	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Endocrinology Cancer
Estradiol (Standard) is the analytical standard of Estradiol. This product is intended for research and analytical applications. Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-N0949

(-)-Variabilin
(-)-Variabilin (compound 13) is an Neurogenin2 (Ngn2) promoter activator isolated from Butea superba. (-)-Variabilin promotes differentiation of neural stem cells into neurons .

HY-12323

ISX-9 5+ Cited Publications Isoxazole 9	Calcium Channel	Neurological Disease
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca ²⁺ influx through both voltage-gated Ca ²⁺ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) .

HY-122788

N-Oleoyl serinol Oleoyl serinol	Apoptosis	Cancer
N-Oleoyl serinol is a ceramide analog that can be used in stem cell therapy to prevent stem cells from developing into teratomas. N-Oleoyl serinol induces apoptosis in residual pluripotent embryoid body-derived cells (EBCs), prevents teratoma formation, and enriches EBC cells that undergo neural differentiation after transplantation .

HY-N2045

Musk ketone 1 Publications Verification
Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis .

HY-116461

ML-184 CID2440433	GPR55	Neurological Disease
ML-184 (CID2440433) is a selective GPR55 agonist with an EC₅₀ of 250 nM and exhibits >100-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55 . ML-184(CID2440433) increases proliferation of neural stem cells and promotes neuronal differentiation in vitro .

HY-13418G

Dorsomorphin dihydrochloride Compound C dihydrochloride; BML-275 dihydrochloride	AMPK	Neurological Disease Cancer
Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs) .

HY-N6588

3,4,5-Tricaffeoylquinic acid 3,4,5-triCQA	Akt NF-κB	Inflammation/Immunology
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases .

HY-133028

CKI-7 free base	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases .

HY-W011109

CKI-7	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases .

HY-W019870

Glufosinate ammonium	Others	Neurological Disease
Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity .

HY-W019870A

Glufosinate	Others	Neurological Disease
Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity .

HY-12318G

IBMX 3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine	Phosphodiesterase (PDE)	Inflammation/Immunology
IBMX (3-Isobutyl-1-methylxanthine) (GMP) is IBMX (HY-12318) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor .

Cat. No.	Product Name

HY-L017

Stem Cell Signaling Compound Library	1740 compounds
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 1740 compounds that can be used for stem cell regulatory and signaling pathway research.

Stem Cell Signaling Compound Library

1740 compounds

Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.

MCE owns a unique collection of 1740 compounds that can be used for stem cell regulatory and signaling pathway research.

HY-L013

Neuronal Signaling Compound Library	2542 compounds
Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders. MCE designs a unique collection of 2542 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Neuronal Signaling Compound Library

2542 compounds

Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders.

MCE designs a unique collection of 2542 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

Cat. No.	Product Name	Type

HY-12323G

ISX-9 (GMP)

Isoxazole 9 (GMP)
Fluorescent Dye

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation.

ISX-9 (GMP) Isoxazole 9 (GMP)	Fluorescent Dye
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation.

HY-13418G

Dorsomorphin dihydrochloride (GMP) Compound C dihydrochloride (GMP); BML-275 dihydrochloride (GMP)	Fluorescent Dye
Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs) .

Dorsomorphin dihydrochloride (GMP)

Compound C dihydrochloride (GMP); BML-275 dihydrochloride (GMP)

Fluorescent Dye

Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs) .

HY-12318G

IBMX (GMP) 3-Isobutyl-1-methylxanthine (GMP); Isobutylmethylxanthine (GMP)	Fluorescent Dye
IBMX (3-Isobutyl-1-methylxanthine) (GMP) is IBMX (HY-12318) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor .

Cat. No.	Product Name	Type

HY-12323G

ISX-9 (GMP)

Isoxazole 9 (GMP)
Biochemical Assay Reagents

ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation.

ISX-9 (GMP) Isoxazole 9 (GMP)	Biochemical Assay Reagents
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation.

HY-13418G

Dorsomorphin dihydrochloride (GMP) Compound C dihydrochloride (GMP); BML-275 dihydrochloride (GMP)	Biochemical Assay Reagents
Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs) .

Dorsomorphin dihydrochloride (GMP)

Compound C dihydrochloride (GMP); BML-275 dihydrochloride (GMP)

Biochemical Assay Reagents

Dorsomorphin dihydrochloride (GMP) is the GMP level of Dorsomorphin dihydrochloride (HY-13418). GMP guidelines are used to produce Dorsomorphin dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Dorsomorphin dihydrochloride (GMP) is a potent, selective and ATP-competitive AMPK inhibitor. Dorsomorphin dihydrochloride (GMP) can be used for the research of induced differentiation of pluripotent stem cells (PSCs) .

HY-12318G

IBMX (GMP) 3-Isobutyl-1-methylxanthine (GMP); Isobutylmethylxanthine (GMP)	Biochemical Assay Reagents
IBMX (3-Isobutyl-1-methylxanthine) (GMP) is IBMX (HY-12318) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0141

Estradiol 55+ Cited Publications β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol	Structural Classification Classification of Application Fields Source classification Endocrine diseases Endogenous metabolite Monophenols Sunscreen Disease markers Phenols Cosmetic Research Disease Research Fields Steroids Cancer	Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-B0141R

Estradiol (Standard) 55+ Cited Publications β-Estradiol(Standard); E2(Standard); 17β-Estradiol(Standard); 17β-Oestradiol (Standard)	Structural Classification Classification of Application Fields Sunscreen Source classification Disease markers Phenols Endocrine diseases Cosmetic Research Endogenous metabolite Disease Research Fields Steroids Cancer	Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Estradiol (Standard) is the analytical standard of Estradiol. This product is intended for research and analytical applications. Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-N6588

3,4,5-Tricaffeoylquinic acid 3,4,5-triCQA	Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Convolvulaceae Ipomoea batatas (Linn.) Lamarck	Akt NF-κB
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases .

HY-N2740

Agalloside	Structural Classification Flavonoids Flavones Thymelaeaceae Source classification Plants Aquilaria sinensis (Lour.) Spreng.	Others
Agalloside is a neural stem cell differentiation activator that can be found in Aquilaria agallocha .

HY-N1838

Dehydromaackiain	Structural Classification Natural Products Leguminosae Source classification Plants Butea superba Roxb. ex Willd.	Others
Dehydromaackiain is a potent Neurogenin2 (Ngn2) promoter activator. Dehydromaackiain promotes differentiation of neural stem cells into neurons .

Cat. No.	Compare	Product Name	Species	Source

HY-P71168

	NPDC-1 Protein, Human (HEK293, His) neural proliferation differentiation and control protein 1; NPDC-1; NPDC1; RP11-229P13.1; CAB; CAB-1; CAB1	Human	HEK293
	NPDC-1 protein critically hinders oncogenic transformation in neural and non-neural cells, suppressing neural cell proliferation. Its multifaceted impact extends to transcriptional regulation, emphasizing its role as a regulator with implications for mitigating oncogenic processes and modulating cellular proliferation in diverse cell systems. NPDC-1 Protein, Human (HEK293, His) is the recombinant human-derived NPDC-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NPDC-1 Protein, Human (HEK293, His) is 147 a.a., with molecular weight of 28-35 kDa.


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Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

neural differentiation

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Natural
Products